A Danish researcher has made a groundbreaking discovery that can essentially lead to patients experiencing fewer side effects and reduce their medicine intake. The discovery, made by Alex Rojas Bie Thomsen and his team, explains a so-called paradox that occur in the body when taking medicine. The paradox describes how the same medicine lead to severe side effects in some patients and leave other patients overly medicated, but not why this is the case.
When taking medicine, the body’s most important proteins, G protein coupled receptors, or GPCR send signals from the cell membrane to the cell core. 30-50 pct. of all pharmaceuticals use GPCRs.
In order not to be over-stimulated, cells have developed a slowing mechanism, b arristin, which inhibits the GPCR signal. Some GPCRs however, keep sending signals to the cell despite the slowing mechanism. This is the center of the paradox.
The Danish discovery shows that some receptors tie b arristin in a way that inhibits its slowing mechanism. This is referred to as a ’mega complex’ and has previously been unknown.
Mapping the previously unknown GPCR signaling mechanisms of the cells paves the way for pharmaceuticals that strategically target these mechanisms and thereby making the effects of medicine easier to control.
The research results have been published in the journal CELL.
Read the CELL article here