The main purpose of the Danish National Biobank is to give scientists from Denmark and abroad overview and access to more than 22 million biological samples in both existing and future collections. Scientists have the possibility to link information about biological samples in Danish biobanks with the large amount of information contained in Danish administrative registries. The Danish National Biobank is still expanding, and will become one of the world’s largest biobanks and a unique resource that will take Danish biomedical research another step forward.
Through a national collaboration, large Danish biobanks, at hospitals, universities and other research institutions, regularly submit information about their biological samples to the Danish Biobank Register. Data from the biobanks are linked to register information, so biological samples can be cross-referenced to diseases, operations, demographic information and much more. Samples can be taken at time of diagnosis, but also years before, enabling early biomarkers to be identified. Aggregated results about the available biological material is displayed to researchers around the world through a web-based search system, that so far contains information about 22 million biological samples from 5.4 million Danes. Learn more
By using the Danish Biobank Register, Bjarke Feenstra and collaborators were able to identify 2000 blood samples in the Danish National Biobank from children experiencing Febrile Seizures (FS). In rare situations, FS occur as an adverse event following MMR vaccination. Through genome-wide association analyses, the researchers identified two genetic variants that specifically predispose to FS after MMR vaccination. The study also identified four variants for FS in general. The large sample size available through the Danish National Biobank, made it possible to delineate the genetic contribution to FS in children, thereby opening a completely new chapter in seizure genetics. Learn more